1Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China 2Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China *Correspondence to:Kenneth King Yip Cheng , Email:kenneth.ky.cheng@polyu.edu.hk Weiping Jia , Email:wpjia@sjtu.edu.cn